|
KMID : 0644120200330020044
|
|
Journal of Oriental Gynecology
2020 Volume.33 No. 2 p.44 ~ p.62
|
|
|
Herbal Medicine for Cervical Intraepithelial Neoplasia After Loop Electrosurgical Excision Procedure : A Systematic Review and Meta-Analysi
|
|
Lee Su-Jeong
Ji Hae-Ri
Lee Hye-Jung
Hwang Deok-Sang
Lee Chang-Hoon
Jang Jun-Bock
Lee Jin-Moo
|
|
|
Abstract
|
|
|
Objectives : The purpose of this study is to evaluate the effectiveness of herbal medicine for recovery and treatment of cervical intraepithelial neoplasia(CIN) after loop electrosurgical excision procedure(LEEP).
Methods : We searched two english, one chinese and four korean database up to November 4, 2019. Randomised controlled trials(RCTs) were eligible. Primary outcome included HPV clearance rate and the effective ratio of treatment. And vaginal bleeding time and volume, improvement of symptoms, and recovery of wound were regarded as secondary outcomes. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool.
Results : Of 47 screened, 10 RCTs were included. Number of participants per study ranged from 58 to 360. The studies which used HPV clearance rate as primary outcome were considered as low risk of bias. Most of the studies had considerable heterogeneity in terms of type of intervention, comparison and time-points for outcome measurement. Compared to LEEP alone, herbal vaginal suppository combined group showed favorable results for HPV clearance in patients(5 studies, n=627, 95% CI 1.26 to 1.55, I²=75%). And compared to LEEP alone, herbal external application also showed favorable results for HPV clearance in patients(2 studies, n=252, 95% CI 1.19 to 1.61, I²=86%). Three studies reported mild and temporary adverse events, and no serious adverse events were reported.
Conclusions : The studies showed that herbal medicine can significantly effective on recovery of CIN after LEEP. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for CIN after LEEP and reduce the risk of bias.
|
|
|
KEYWORD
|
|
|
Herbal Medicine, Cervical Intraepithelial Neoplasia, Cervical Dysplasia, Human Papilloma Virus, Loop Electrosurgical Excision Procedure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|